Don't be afraid to use expensive glass. Here is how I look at it...
You pay $25 per 1/4#.
You sell a set of beads made from it for $25 or more (a single focal is even better because that uses less glass than a set).
You should have about 3-4 rods left from the 1/4# bundle.
You made up your cost in that $25 sale and now the remaining rods mean extra profit over and above the cost of the glass.
Depending on how I use expensive glass, I can make double or triple the cost of the glass in my final product.
Don't be afraid to use it - whether it's DH or odd lots! It pays for itself (if you sell your beads that is).